DEUBIQUITINATION OF EPIDERMAL GROWTH FACTOR RECEPTOR BY UBIQUITIN-SPECIFIC PEPTIDASE 54 ENHANCES DRUG SENSITIVITY TO GEFITINIB IN GEFITINIB-RESISTANT NON-SMALL CELL LUNG CANCER CELLS.

A precise balance between ubiquitination and deubiquitination is crucial for cellular regulation.Ubiquitin-specific peptidase 54 (USP54), an active deubiquitinase (DUB), modulates the ubiquitination of the epidermal growth factor receptor (EGFR).While the significance of USP54 in tumorigenesis is known, its specific function in cancer progression C

In the title molecule, C17H17NO4, the dihedral angle between the two aromatic rings SR is 42.47 (7)°.The nitro group is twisted by 7.44 (11)° out of the plane of the ring to which it is attached.The methoxy and ethoxy group O atoms deviate significantly from the phenyl ring [by 0.0108 (11) and 0.0449&

This study investigates how and when general self-efficacy is related to entrepreneurial intentions.We propose that entrepreneurial outcome expectations function as a mediator in this relationship, while subjective norms act as a moderator.Using a sample of FRUIT SAMPLER 1052 students from U.S.Public Universities, we tested a moderated mediation mo

Transposable elements (TEs) are self-replicating DNA elements that constitute major fractions of eukaryote genomes.Their ability to transpose can modify the genome structure with potentially deleterious effects.To repress TE activity, host cells have developed numerous strategies, including epigenetic Jars pathways, such as DNA methylation or histo

Understanding the complex interactions between urbanization and ecosystem services (ESs) is crucial CLEAN COFFEE MEDIUM ROAST for optimizing planning policies and achieving sustainable urban management.While previous research has largely focused on highly urbanized areas, little attention has been given to the phased effect of progressive urbanizat